Aim To study the abnormalities of lipoprotein and apoliprotein in patients with acute myocardial infarc-tion(AMI),unstable angina pectoris(UAP)and stable angina pectoris(SAP).Methods The subjects studied were 21 cases with AMI,27 cases with UAP,35 cases with SAP and 50cases as controls.The serum lipids and lipoprotein and apolipoprotein of each fasting serum were exam-ined simultaneously.Results 1.In AMI.UAP and SAP groups the serum levels of Lp(a)(360±364mg/L,297±301mg/L and 232±200mg/L respectively),Apo B100(0.89±0.28g/L,0.90±0.24g/L and 0.84±0.25g/L re-spectively)and Apo E(43.4±8.3mg/L,42.8±10.6mg/L and 42.6±8.1mg/L respectively)were signifi-cantly higher than that in healthy control group(Lp (a)124±110mg/L,Apo B1000.62±0.16g/L and Apo E 34.5±8.0mg/L);while in AMI,UAP and SAP groups.serum levels of HDLC(1.12±0.29mmol/L,1.18±0.25mmol/L and 1.25±0.28mmol/L respectively).HDL2C(0.35±0.14mmol/L,0.37±0.12mmol/L and 0.37±0.11 mmol/L respectively)and Apo AI(1.09±0.23g/L,1.09±0.24g/L and 1.13±0.23g/L respectively)were signifi-cantly lower than that in healthy control group(HDLC 1.405±0.26mmol/L,HDL2C 0.49±0.26mmol/L and ApoAI 1.25±0.21g/L).2.The ratio of LDLC/HDLC was higher in AMI group than that in SAP group.3.In serum lipid abnormality detectable rat in AMI,UAP and SAP groups,the increased serum Apo B100(53.13% to 57.89%),Apo E(43.48% to 63.64%)were the highest;and the next was the decreased HDLC(39.39% to 62.96%).In serum lipid abnormality pattern in AMI,UAP and SAP groups the increased LP(a)(37.97%)was the most frequent one.Conclusion Increased Lp(a).ApoB100.ApoE and decreased HDLC play an important role in coronary heart disease(CHD)and increased ratio of LDLC/HDLC is a predictor of CHD.