Aim To ivestigate the association of lipid metabolism disturbance with haemostatic activity and fibrinolytic activity.Methods Serum lipids,some plasma haemostatic and fibrinolytic parameters were determined in 61 pa-tients with hyperlipidemia(hypertriglyceridemia in 45and mixed hyperlipidemia in 16)and compaerd with those in 18 healthy controls.Results The plasma activities of type-1 plasmino-gen activitor inhibitor(PAI-1),coagulation factor VII (F VII)and X(F X)were significantly higher,tissue type plasminogen activitor(tPA)was significantly lower in hyperlipidemic patients when compared with those in healthy controls(P<0.05~0.001). Fur-thermore serum triglyceride level was positively corre-lated with plasma activities of PAI-1,F VII and F X(P <0.05~0.001),and negatively correlated with tPA activity(P<0.01).Serum cholesterol level was also positively correlated with plasma fibrinogen level and PAI-1 activity(P<0.05).Conclusion Hyperlipidemia,especially hyper-triglyceridemia may increase coagulation activity and decrease fibrinolytic activity,benefiting the formation of thrombosis.Therefore,hyperlipidemia is an im portant risk factor for atherosclerosis.