Aim To study the effects of benazepril and ni-trendipine on renal hemodynamics and urinary β2-mi-croglobulin(β2-MG)in the hypertensive patients.Methods A randomized-cross trial comparison of benazepril and nitrendipine in the treatment of 58 hy-pertensive patients divided into two groups for 4 weeks was preformed.The renal hemodynamics and urinary β2-MG were determined in all patients before and after treatment.The urinary β2-MG was measured with ra-dioimmunoassay and renal hemodynamics was detected by means of radionuclide.Results Benazepril not only increased the effective renal plasma flow,but also significantly reduced the filtration fraction and urinary β2-MG(P also<0.01)after treatment.There was no change on the renal hemodynamics and β2-MG after the treatment of ni-trendipine.Conclusion The data indicate that benazepril could improve the renal function better than nitrendipine in the hypertensive patients.