Aim To investigate enalapril, nifedipine and lovastatin had the effects on experimental atherosclerosis in cholesterol rabbits. Methods Thirty seven rabbits were divide into five groups accidentally. Group A received normal chow, group B received cholesterol, group C received cholesterol plus enalapril, group D received cholesterol plus nifedipine and group E received cholesterol plus lovastatin. All rabbits were fed for sixteen weeks. At the end of the study, all animals were killed to determine the aortas cholesterol concentration and the percentage of aortic lesions covering the intimal surface. Results Enalapril and nifedipine didn’t affect lipid level. Lovastatin reduced total cholesterol, triglyceride, and LDL level. The LDL/HDL ratio was less in lovastatin group than that in cholesterol, enalapril, and nifedipinegroups. The aortas cholesterol concentration and the plaque square in all drug groups were lower than in cholesterolgroup (P<0.05). Conclusion These three drugs had the effects of prophylaxis in experimental atherosclerosis.