Aim To study the effects of insulin like growth factor 1(IGF 1) on the occurence and development of hypertension. Methods The IGF 1 content in plasma and tissues of Witar kyoto rats (WKY) and spontaneously hypertensive rats (SHR) was detected by means of radioimmunoassay. Results In SHR, the content of IGF 1 was markedly increased in heart (P<0.05) and also slightly in plasma (P>0.05), but obviously decreased in liver (P<0.05). Both in WKY and in SHR the content of IGF 1 was found to be the highest in the liver. Conclusion These data suggest that the changes of IGF 1 content and distribution in SHR might associate with the pathogenesis of hypertension. 还原