Aim To evaluate the effect of statins on serum triglyceride in patients with hyperlipidemia, and whether the effect is related to baseline triglyceride levels. Methods The data analysed were originated from 2 separate multicenter clinical trials with similar designs. Baseline total cholesterol lecels was more than 5.98 mmol/L, and baseline triglyceride lecels was less than 4.52 mmol/L. The patients were grouped by baseline triglyceride levels. 166 patients had participated in Simvastatin Clinical Trial with simvastatin 10 mg once daily for 8 weeks. 146 patients had participated in Lovastatin Clinical Trial with lovastatin 20 mg once daily for 8 weeks. Results It showed that the higher the baseline triglyceride levels were, the more effective the simvastatin or lovastatin was in reducing serum triglyceride lecels. A positive correlation was found between baseline triglyceride levels and effects of simvastatin (r=0.3155,P<0.01) and lovastatin (r=0.3341,P<0.01) in reducing serum triglyceride lecels . Conclusions statins was effective in decreasing triglyceride levels in patients with hypertriglyceridemia. The change of reduction on triglyceride was closely related to baseline triglyceride lecels.