Aim To compare the lipid-lowering efficacy and security of zocor with homemade-simvastatin. Methods 40 patients with Hypercholesterolemia were randomized into two groups, 20 patients in simvastatin group, the others in zocor group as controls. Serum lipids levels were determined prior to lipid lowering treatment and at the end of 4 and 8 week treatment respectively. Results At the end of 4 and 8 week treatment, levels of total cholesterol (TC), low density lipoprotein chdesterol (LDLC) and TC/HDLC (high density lipoprotein chdesterol) in both groups significantly reduced (P<0.01), while HDLC significantly raised (P<0.01). At the end of 8 week treatment, levels of triglyceride (TG) in zocor group significantly reduced (P<0.01), while not in simvastatin group. There was no obvious side effects during the period of homemade-simvastatin and zocor treatment and the patient's tolerance was good. Conclusion Homemade-simvastatin is a effective medicine for the treatment of hypercholesterolemia.