Aim To investigate the effect of fluvastatin on endothelial, coagulative and fibrinolytic functions in experimental atherosclerotic rabbits. Methods 28 male New Zealand rabbits were divided into four groups randomly: normal group,pathological group, 5-week fluvastatin-treatment group (10 μg/g.d )and 9-week fluvastatin-treatment group (10 μg/g.d ). Plasma 6-Keto-prostaglandin F 1α (6-Keto-PGF 1α ),thronboxane B 2(TXB 2),endothelin (ET), nitric oxide (NO), tissue-plasminogen activator (tPA), plasminogen activator inhibitor (PAI) and fibrinogen (FIB) concentrations were assayed in different intervals during the experiment. Results At the end of ninth week,TXB 2/6-keto-PGF 1α ratio, ET levels and PAI levels in the two treat groups were significantly lower than those in the pathological group (P<0.05); TXB 2 concentration in the pathological group was much higher than that in the normal group (P<0.05). NO and tPA concentrations in the pathological group were significantly lower than those in the normal group (P<0.01). Compared with the pathological group, the concentration of 6-Keto-PGF 1α in two treatment groups had a increasing trend, but the concentration of FIB had a lowering trend. Conclusion Fluvastatin can significantly improve endothelial, coagulative and fibrinolytic functions.