Aim [WT5”BZ]The present study was to compare the clinical efficacy of low dose gemfibrozil with normal dose gemfibrozil administered in hyperlipidemic patients. [WT5”HZ]Methods [WT5”BZ]121 subjects were randomized into two groups: 62 Subjects in low dose gemfribrozil group,59 subjects in normal dose gemfibrozil group as controls. Blood lipid levels were determined prior to lipid lowering treatment and at the end of 4th and 8th week treatment respectively. [WT5”HZ]Results [WT5”BZ] At the end of the 4th week treatment, levels of TC and TG in normal dose gemfibrozil group significantly reduced (P<0.01), and levels of HDLC in normal dose group obviously increased (P<0.01), only levels of TG in low dose group reduced (P<0.05), after treatment compared with the prior to treatmant. At the end of the 8th week treatment, levels of TC and TG significantly reduced and levels of HDLC obviousely increased in both groups. Both of difference were statistically significant (P<0.01). [WT5”HZ]Conclusion [WT5”BZ] Not only was the efficacy of low dose group significantly weaker than that of normal dose group but also the side effects of low dose group was lower