Aim [WT5”BZ]To study whether serum non-high density lipoprotein cholesterol (nHDLC) level is related to coronary heart disease (CHD). [WT5”HZ]Methods [WT5”BZ]The triglyceride, total cholesterol and high density lipoprotein cholesterol in the serum of 183 patients with coronary heart disease with hyperlipoproteinemia and 194 healthy individuals were tested separately. The low density lipoprotein cholesterol and the very low density lipoprotein cholesterol were calculated according to Friedewald`s formula LDLC = TC - (HDLC + 0.458 TG) and the non-HDL Ccontent was calculated with Frost method. [WT5”HZ]Results [WT5”BZ]There was significant difference in serum low density lipoprotein cholesterol (LDLC) level and nHDLC level between the CHD with Ⅱa and Ⅱ_b patient group and control group (P<0.001). There was no significant difference in serum LDLC level between the CHD with Ⅳ patient group and control group (P>0.05), while serum nHDLC level was significantly higher in CHD with Ⅳ patient group than control group (P<0.001). [WT5”HZ]Conclusions [WT5”BZ] This article provides examples of the utility of non-HDL cholesterol concentrations in clinical medicine.