Aim To study the effects of mannan, chitin, orosomucoid and cucurmin on the metabolism of lipoprotein (a) and desialylated lipoprotein(a). Methods Mannan, chitin, orosomucoid and cucurmin was injected into the body of hedgehogs via the armpit vein 2 min before the 125 I-Lp(a) or 125 I-dsLp(a). The animals was put to death in an hour. The radioactivity 125 I-Lp(a) and 125 I-dsLp(a) in the blood, liver, kidney, spleen, gall and adrenal were measured. Results The absorption of dsLp(a) in the liver is larger than that of Lp(a). It makes the concentration of dsLp(a) decrease in blood. Orosomucoid is a strong inhibitor of catabolism of Lp(a) and dsLp(a). It can inhibit the absorption of Lp(a) and dsLp(a) by the mentioned tissue and makes the concentration of Lp(a) and dsLp(a) in the blood increase. The effects of chitin and cucurmin are similar. They can increase the absorption of Lp(a) by liver and adrenal and make the concentration of Lp(a) decrease in blood. The effects of chitin and cucurmin can affect the metabolism of Lp(a), but not dsLp(a). The effects of mannan on the metabolism of Lp(a) and dsLp(a) are little. It can increase the absorption of Lp(a) by spleen and reduce the concentration of Lp(a) in the gall. Moreover, it can increase the absorption of dsLp(a) by kidney and gall, reduce the absorption of dsLp(a) by adrenal. Conclusions It is the key step of catabolism of Lp(a) that Lp(a) is desialylated. Sailic acid in Lp(a) molecular play an important role in its stability of structure. The experiments show that orosomucoid can inhibit the metabolism of Lp(a) and dsLp(a), chitin and cucurmin can promote the matabolism of Lp(a).