Aim To explore the relationship between the urinary albumin fragments(uAF) and cardiovascular damage. Methods The improved western blot was employed for analysis of uAF in urine of the patients with cardiovascular damagied disorders. Sample from 112 patients with non-diabetic primary hypertension, 46 coronary artery disease and 36 cerebrovascular disease as well as 108 healthy volunteers were examined. Results The anomalous fragments (45 kDa, 30 kDa, 22 kDa)are detected in the urine of patients with cardiovascular damagied disorders, the prevalences of uAF in hypertension, coronary artery disease, cerebrovascular disease and healthy volunteers were 32.33%, 60.87%, 66.67% and 5.00% respectively, the incidence of detection of uAF in these patients is significantly higher than that in healthy voluntees(P<0.01). uAF is related to MAU, TG and TC. Conclusions uAF and ardiovascular damage are significantly related, uAF can be used as a new reference indicator of non-injury for determining cardiovascular damage.