Aim To investigate the relationships between plasma calcitonin generelated peptide (CGRP) and the severity of coronary lesions and left ventricular function in patients with coronary heart disease. Methods In 42 patients with fixed stenosis coronary artery ≥70% of luminal diameter in the major coronary arteries and 15 normal persons, the concentration of plasma CGRP was measured using radioimmunoassay (RIA). The relationships between plasma CGRP and the Leaman coronary artery score as well as left ventricular ejection fraction (LVEF) were assessed. Results The concentration of plasma CGRP was obviously lower in the coronary disease group than in the control group (276.12±164.75 ng/L vs 411.44±110.32 ng/L,P<0.01). The concentration of plasma CGRP was negatively related to the Leaman score (r=-0.61,P<0.001) and positively to LVEF (r=0.57,P<0.001). The Leaman score had no significant correlation to LVEF in the whole group. However, in the subgroup with the level of plasma CGRP<250 ng/L, the Leaman score had significantly negative correlation to LVEF (r=-0.49,P<0.05). Conclusions The plasma CGRP had correlation to both the severity of coronary lesions and left ventricular function in patients with coronary heart disease. In the patients with decreased concentration of plasma CGRP, the left ventricular function deteriorated with the progress of coronary lesions.