Aim To determine whether coronary heart disease is associated with infection with Helicobacter pylori(HP). Methods Epidemiological and clinical studies published in full in English before October 2000 that reported on correlations between infection with HP and coronary heart disease were identified by searching Medline and medical journals. Results 20 reports available for analysis were collected. the relation between coronary heart disease and infection with HP were analysised by means of Fixed effect model of Meta-analysis. The involved total of subjects were 9737, and 4283 were patients. Mean age of the subjects in 18 studies was under 65 years. Of them the pooled odds ratio(OR) of 12 case-control studies was 1.96. OR 95 % CI was 1.76～2.18. The pooled OR of 6 cohort studies was 1.21 (95% CI, 1.07 ～1.35). Two studies that mean age of their subjects was over 70 years showed that coronary heart disease was not associated with Infection with HP. 4 studies on association between coronary heart disease and infection with CagA positive stains of HP were collected. Meta analysis showed that coronary heart disease was associated with infection, with a pooled OR of 1.52 (95%CI, 1.26～1.84). Conclusions Infection with HP was associated with coronary heart disease. Very large randomised trials would be needed to determine whether association is causal.