Aim To investigate the relationship between plasma Hcy level and conventional risk factors of CHD in MI patients. Methods 104 cases with myocardial infaction (MI) and 104 controls were recruited to participate the study. Plasma total Hcy were measured while subjects were fasting using fluorescence polarization immunoassays (FPIA). Conventional risk factors of CHD such as sex, familial history, smoking, blood pressure,blood glucose,serum choleserol,serum triglycerides,age,uric acid,creatinine and quetelet index were also measured. Results The mean plasma Hcy level was 25.17±9.31 μmol/L for MI patients, 18.41±8. 03 μmol/L for controls. Statistically, the mean plasma Hcy levels of MI patients were significantly higher than that of the controls(P<0.01). By multivariate non-conditional Logistic regression analysis,the final model consists of smoking(Or=1.066), hypertension(Or=1.128),hypercholesterolemia(Or=6.511)and Hcy(Or=2.875),which have significant relation with MI. Conclusion Hcy has strong relation with MI. Its OR was second compared with other conventional risk factors in MI patients by Logistic regression analysis.