Aim To investigate the changes of lipid and the insulin resistance non diabetes first degree relatives of 2 type diabetes mullitus families. Methods The fasting insulin (FINS), total cholesteral (TC), triglyceride (TG) and high density lipoprotein (HDL) were measured in diabetes mullitus (DM) group, impaired glucose tolerance (IGT) group and non diabetes first degree relatives (FDR) group of 2 type diabetes mellitus families. Their spouses were selected as control group. The oral glucose tolerance test (OGTT) were conducted in all grops. The insulin resistance were assessed by insulin sensitive index (ISI)=1/FPG (fasting plasme glucose) × FINS. Results TG in DM group, IGT group and FDR group was markedly elevated (P<0.01 andP<0.05). HDL level and ISI in DM group, IGT group and FDR group were lower (P<0.05 andP<0.01). Conclusion Insulin resistance and lipid abnormalities appear early (before the development of IGT and DM) in first degree relatives of 2 type DM.