Aim To investigate the relationship between triglyceride (TG) concentration and tissue plasminogen activator (t-PA) activity, and analyze comparatively. plasminogen activator inhibitor-1 (PAI-1) activity in patients with different types of coronary heart disease (CHD) and high TG concentration. Methods TG concentrations of 73 patients with different types of CHD and 40 patients with high TG concentration and 40 controls were measured. Meanwhile, t-PA and PAI-1 activity were determined. Results PAI-1 activity in patients with high TG or CHD were higher than those of the control group, but t-PA activity were lower than those of the control group in patients with high TG and acute myocardial infarction (AMI) or unstable angina pectoris (UAP) at same time. TG positively correlated with PAI-1 activity but negatively correlated with t-PA activity. Conclusion TG may play an important role in the pathogenesis of CHD by inducing fibrinolytic dysfunction