Aim The present study was to investigate the effe cts of Fluva statin on vascular smooth muscle cells (VSMC) proliferation in atherosclerotic model of iliac artery of rabbit after endothelial denudation. Method s The New Zealand White Rabbits were randomized into Fluvastatin group (n=28) and control group(n=28). The atheroscl erotic lesions were developed by inducing endothelial denudation with balloon ca theter and being given high dosag e of cholesterol diet at the same time. The experimental animals were killed an d iliac arteries were removed at 1, 2, 4, 8 week after endothelial injury respect i vely. Through the methods of routine immunohistochemical staining and image ana l ysis system, we observed the effects of Fluvastatin on the expression between pr oliferating cell nuclear antigen (PCNA) and platelet derived growth factor BB (PDGF BB) in neointima. Results Percentages of PCNA postiv e cells in the intima of Fluvastatin group was lower than that in control group apparently. The content of PDGF BB in Fluvastatin group was al ways at a lower level and even lower than that in control group (p<0.05). Coefficient of linear correlation of PCNA with PDGF BB was 0.7127( p<0.01). Conlusion Fluvastatin may partly in hibit VSMC proliferation through decreasing the synthesis of PDGF BB.