Aim To investigate the relationship between cor onary artery disease and hypertriglyceridemia? hypo high density lipoprotei nemia. Methods 54 cases with stable angina pectoris or old myocardial infarction were divided into four groups: 15 cases in non major risk factor group, 11 cases in hypertriglyce ridemia and hypo high density lipoproteinemia group, 15 cases in diabetes mel litus g roup, and 13 cases in diabetes mellitus and hypertriglyceridemia and hypo high densit y lipoproteinemia group. Some risk factor such as smoking years, blood glucos e, systolic blood pressure, choleserol, low density lipoprotein cholesterol(LDLc ), trig lyceride, high density lipoprotein cholesterol (HDLc) were measured. The rel ationship between above factors and the degrees of coronary artery lesion with a ngiography were detected. Results The coronary arter y stenosis s core was significantly higher in diabetes mellitus and hypertriglyceridemia, and hypo high density lipoproteinemia group (10.5±3.4) than in other groups (p<0.05), the B 2?C type of coronar y artery disease in diabetes mellitus and hypertriglyceridemia and hypo high d en sity lipoproteinemia group were significantly more than in non major risk fac tor group (p<0.05), and three vessel diseases increase more in this group; the lineal regression relationship were found between blo od glucose, triglyceride, HDLc and coronary artery stenosis score with stepwise regression analysi s. Conclusions The higher the levels of blood gluc ose and triglyceride become, the lower the level of HDLc. The coronary artery s tenosis score will become higher, with the degree of coronary artery lesion be coming heavier.