Aim To study the effect of fluvastatin on serum l ip id and adhesive molecules. Methods 58 patients wit h hyperlipidemia (male 35, female 23) received fluvastatin 40 mg, po, for one week and then the dosage were reduced to 20 mg night. The therpeutic course wa s 6 8 week. Results After treatment the average lev els of serum TC, TG, LDL, soluble intercellular adhesion molecule (sICAM) 1 and soluble vascular cell adhesion molecule (sVCAM) 1 were lowered significantly (p<0.05), but HDL was not significantly elevated. Conclusion Fluvastatin not only decreased TC,TG and LDL, but als o decreased sICAM 1 and sVCAM 1 concentration.