Aim Investigate the Protective Effect of Shou-Gong Shui-Zhi Composition on Regional Cerebral Ischemia Reperfution Injury in Rats. Methods Acute cerebral ischimia reperfution injury model in the rat was established by introducing nylon suture into middle cerebral artery (MCA) for occlusion and then taking out the nylon suture. The behavior obstacle marks of rats was studded, and the water contents in brain,LDH and CK activity in serum,Na +, K +,Ca 2+ , Mg 2+ levels of cerebral tissue was measured. Results Shou-Gong Shui-Zhi Composition can enhance the behavior obstacle marks of rats, decrease contents of H 2O, LDH, CK activity and Na + levels after ischemia reperfution. Conclusion Shou-Gong Shui-Zhi Composition could protect brain ischemia reperfution injury