Aim To study the hemodynamic effects of fructose 1,6 diphosphate (FDP) in patients with coronary artery disease (CAD) complicated with chronic heart failure (CHF). Methods 10 g FDP was intravenously infused in 47 cases of CAD with CHF. Heart rate (HR), mean arterial pressure (MAP), ejection fraction (EF), stroke volume (SV), stroke index (SI), cardiac output (CO), cardiac index (CI) and fractional shortening (FS) were measured before, 30 min and 60 min after the infusions. Results The results indicated that apart from EF 30 min after versus before the infusions, all of the cardiac function parameters dramatically increased after the treatment while the augmentations were larger in 120 min than in 30 min after the treatment. Conclusions FDP intravenous administration in patients with CAD complicated with CHF could improve the hemodynamic status and cardiac function. The drug possessed positive inotropic property but would not increase O 2 consumption.