Aim To investigate the effect and the heart protecting mechanism of manshuailing oral liquid on plasma soluble intercellular adhesion molecular 1 (sICAM 1) level in patients with congestive heart failure (CHF). Methods 120 patients of CHF were randomly divided into 2 groups. 60 cases in the routine treatment group received common therapy, and 60 cases in the manshunailing oral liquid treatment group were treated with additional manshuailing oral liquid except common therapy. 40 normal cases were taken as the control group. The plasma level of sICAM 1 was tested before and after 4 weeks management by enzyme linked immunosorbent assay (ELISA) method. Results The plasma concentration of sICAM 1 in both the treatment groups was higher than the control group even after treating (p<0.01). Compared with that of pretreating, the level of sICAM 1 decreased in both the treatment groups (p<0.01), but the magnitude of change was greater in the manshuailing oral liquid group than in the routine treatment group (p<0.01). Conclusion Manshuailing oral liquid may inhibit ventricular remodeling and improve heart function by decreasing the concentration of sICAM 1 in patients with CHF.