Aim To evaluate the effect of aspirin time-release on the incidence of cerebro-cardiovascular accidents in hypertensive or coronary patients, and to access the influence of age, blood pressure, sex, smoking, et al. Methods This study was an opening, multicenter, randomized, and controlled clinical research. 2 551 patients were enrolled and 2 430 patients had completed the study finally. 1 264 patients were assigned to aspirin time-release 50 mg/d～100 mg/d besides antihypertensive treatment or the routine therapy on coronary heart disease except anticoagulant. The other 1 166 control patients received only routine therapy. Results The study observed that active treatment obviously reduced the incidence of cerebro-cardiovascular accidents (p<0.05 or p<0.001). To compare with the controlled group, the RR (95%) of cerebro-cardiovascular accidents in treated group was 0.341 (0.254～0.460), and the RR of cerebral infarction, cerebral hemorrhage, myocardial infarction was 0.379 (0.258～0.559), 0.203 (0.106～0.388), 0.335 (0.107～1.051) respectively. Furthermore, the RR of death caused by cerebro-cardiovascular accidents was 0.148 (0.052～0.423). After stratifying of blood pressure, the RR of cerebro-cardiovascular accidents was higher in the people with high blood pressure. Conclusions The active therapy with low-dose aspirin could significantly reduce the incidence of cerebro-cardiovascular accidents in high risk group. It is beneficial to control the high risk factors such as blood pressure, smoking, drinking for hypertensive or coronary patients.