Aim To investigate changes of insulin resistance after lipid-lowering treatment by bezafibrate in hypertensive patients with hypertriglyceridemia using calcium channel blockers (nifedipine). Methods Fifty-eight hypertensive hypertriglyceridemic patients were enrolled in study. In random order, patients of group A (30 patients) were treated with bezafibrate, nifedipine and dietary control, and those of group B (28 patients) received placebo, nifedipine and dietary control during 8 weeks. The changes of blood pressure (BP), serum lipid, the levels of plasma glucose and insulin had been examined and compared between two groups. Results The bezafibrate-treated group had a greater reduction in diastolic BP, levels of plasma glucose and insulin, and had a increase in insulin sensitive index. Conclusion Bezafibrate maybe improve the patients' insulin resistance by adjusting dyslipidemia,and maybe extra lower the patients' diastolic BP.