Aim To study whether cease-smoking time takes effect on plasma high sensitive C-reactive protein (hsCRP) and malondialdehyde (MDA) levels of stable angina pectoris patients. Methods 101 subjects in hospital suffering from stable angina pectoris were investigated. The subjects were divided into 3 groups according to their smoking status: smokers, nonsmokers and former smokers who had stopped smoking. The last group were divided again into two subgroups according to different cease-smoking time: long time group and short time group. Levels of plasma MDA were determined by thibabituric acid method, while hsCRP by transmission turbidimetry method. Results Levels of plasma hsCRP and MDA were higher in smokers group than in nonsmokers group (4.82±0.37 mg/L to 1.74±0.31 mg/L,p<0.01; 1.08±0.31 mmol/L to 0.86±0.20 mmol/L,p<0.01); Levels of plasma hsCRP were lower in long time subgroup than in short time subgroup (1.91±0.26 mg/L to 4.66±0.24 mg/L,p<0.05), while levels of plasma MDA have no significant difference in the two subgroups (0.93±0.17 mmol/L to 0.95±0.14 mmol/L ,p>0.05). Conclusion Smoking takes effect on oxidative stress and inflammation to some extent but maybe it takes effect on them for a different time.