Aim To discuss the relationship of abnormal distribution of Ca 2+ and formation of 26 Binswager’s disease, and to find how to prevent the disease. Method Binswager group and control group were detected by flow cytometry. Results IECa 2+ in blood hemocytes was significantly higher in encephalatrophy group than that in control group (p<0.05). In the group with severe cerebral atrophy manifested by computer tomography, IECa 2+ was higher than that of mild and moderate cerebral atrophy group. In the group with dementia, which were detected by the score of intelligent determination, the increase of IECa 2+ was much more remarkable than that of control group and prophase dementia group (p<0.05). Conclusions The formation mechanism of Binswager’s disease was related to abnormal distribution of IECa 2+. The abnormal distribution of IECa 2+ may activate cross-linking of cellular endogenic ribozyme and antibody of T lymphocyte, evoke neurotransmitter release in synapses, change the deformation ability of erythrocyte and aggregation function of platelet, thereby aggravate ischemia of cerebral tissues. Calcium antagonists can prevent Binswager’s disease caused by cerebral circulation disorder.