Aim To investigate the association of the blood von Willebrand factor (vWF) and C-reactive protein (CRP) of diabetes. Methods Blood specimens of 93 new diagnotic diabetic patients whose blood glucose level was more than 10 mmol/L were collected. The vWF and CRP were assayed by ELISA. Results The level of vWF and CRP of diabete group increased significantly than the control normal group, there were not any associative relationship in the level of blood vWF and CRP. Conclusions The elevated concentration of plasma vWF and serum CRP showed that the new diagnotic diabetic patients had the endothelia cell dysfunction and chronic systemic inflammation, vWF and CRP were the independent promoting factor of atherosclerosis.