The Intervention of Polysaccharidesulfate on the Acute Period in the Experimental Cerebral Ischemia Rats
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    Abstract:

    Aim To study the protective effect of polysaccharidesulfate on cell apoptosis in focal cerebral Ischemia-Reperfusion injury rats.Methods Right middle cerebral artery was occlude by inserting a thread through internal carotid artery for 1 h and 30 min,and then reperfused for 24 h. PSS were injected via intraperitoneal of the rats at 30 minutes before or 5 hours after reperfusion.Intra-cellular free calcium([Ca2+]i) and rates of apoptosis an1d death were measured by flow cytometry.The behavior of rats was investigated at the same time.Results The damage of rat's behavior in the PSS-treatment groups was small in comparison with untreated group.The numbers of apoptosis cells were dramatically reduced in the PSS-treatment groups in comparison with untreated group.While the increasing [Ca2+]i was reduced by PSS.These significant difference between 30 min before onset and 5 h after reperfusion groups was also discovered.Conclusions PSS reduced the neuronal damage and inhibited apoptosis induced by ischemia-reperfusion.The anti-apoptosis effects of it might be attributed to its effects by bating the increasing of [Ca2+]i.

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YOU Yong~,YANG QI-Dong~,XIE Hong-Ju~,LIAO Duan-Fang~,and ZHANG Yue-Feng~. The Intervention of Polysaccharidesulfate on the Acute Period in the Experimental Cerebral Ischemia Rats[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2005,13(5):567-569.

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  • Received:October 13,2004
  • Revised:August 10,2005
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