Aim To determine apolipoprotein AI(Apo AI),apolipoprotein E(Apo E),apolipoprotein B₁₀₀(Apo B₁₀₀),lipoprotein(a),LDLC,HDLC,total cholesterol(TC)and triglyceride(TG)in cerebrospinal fluid(CSF) and serum of the pateints with cerebral infarction.Methods In 110 patients with acute cerebral infarction and 60 control subjects,TC and TG was by enzyme assay,lipoprotein(a) and ApoE was measured by ELISA, LDLC and HDLC was by,Apo AI and Apo B₁₀₀ by immunodiffusion assay.Results Compared with the contrals,the level of lipoprotein(a),Apo A_Ⅰ and Apo E in CSF and those of lipoprotein(a),Apo E,Apo B₁₀₀,LDLC and TC,TG in serum of cerebral infarction patients were significantly higher(p<0.01 and <0.05),but the changes of TC and TG in CSF were not significant(p>0.05).Apo A_Ⅰand HDLC levels in serum of cerebral infarction patients were significantly lower(p<0.05).LDL-C,HDLC and Apo B₁₀₀ wasn't found in the CSF in two groups.Every lipids and apolipoproteins levels in the CSF of cerebral infarction patients and contrals were not related to be serum of every lipids and apoliproteins(p>0.05).Conclusions The lipoprotein(a),ApoAI and ApoE levels in CSF in the pateints with cerebral infarction were significantly higher.The lipoprotein(a),Apo E,LDL-C and Apo B₁₀₀ and TG,TC levels in serum in the pateints were significantly higher than those of cortrols,but Apo A_Ⅰand HDL-C levels were significantly lower than those cortrols.