Aim To approach the effect of atorvastatin on C reactive protein(CRP)of patient with acute coronary syndrome(ACS).Methods 46 cases with ACS,which were determined CRP level pre-and post-treatment two weeks,respectively,and compared its difference,were randomly divided into therapeutic drug group and control group,therapeutic group was treated with atorvastatin 40mg daily based on routine treatment(control group).Results 46 cases include 17 cases unstable angina and 29 cases acute myocardial infarction.The CRP level was 1.37±0.52 g/L in angina patient and was 2.23±0.45 g/L in the patient with acute myocardial infarction.And it were higher than that of normal control(0.30±0.22 g/L)(p<0.05),it was significant advanced of CRP in the patient with myocardial infarction than that of the patient with angina(p<0.05).The blood serum CRP level decreased from 1.88±0.45 g/L to 0.52±0.22 g/L(p<0.05) in therapeutic group and has no changes in the control group of the blood serum CRP level decreased from 1.85±0.50 g/L to 1.77±0.60 g/L(p>0.05).Conclusion The CRP is possible to participate the formation of atherosclerosis,and the CRP level was set down obviously of the patients with ACS,it is shown that the atorvastatin can reduce lipid besides anti-inflammatory effect.