Aim To explore the stability of different morphologic types of plaque and its predict value in unstable angina. Methods 85 unstable angina patients and 40 control subject underwent coronary angiography.According to the morphologic types of plaque,the patients with unstable angina were divided into type I(smooth borders) group(n=21) and type Ⅱ (irregular lesions) group(n=45) and type Ⅲ(long lesions) group(n=19).The plasma factor Ⅶ clotting activity and the plasma concentrations of tissue type plasminogen activator(tPA),plasminogen activator inhibitor(PAI),fibrinogen(FG) and D-dimer were measured respectively.56 unstable angina patients were follow-up one year. Results The plasma coagulative and fibrinolytic parameters of the unstable angina group was more extraordinary than those of the control group.In unstable angina group,the coagulative activity of type Ⅱ group was higher than type I and type Ⅲ group(p<0.05) and cardiac events such as acute myocardial infarction and sudden cardiac death were also higher within one year(p<0.01). Conclusion Each morphologic types of plaque were different in both coagulative and fibrinolytic activity and can be used to judge the stability of unstable angina's plaque and to predict prognosis.