Aim To investigate the effect and security of Cypher~ TM stent (sirolimus-eluting stent) in patients with coronary heart disease (CHD). Methods 348 CHD cases were treated with 436 Cypher~ TM stents. Among the 348 patients, 86 had ST-segment elevation acute myocardial infarction (AMI), 21 had non-ST-segment elevation AMI, 149 had unstable angina and 92 had stable angina. As for lesion characteristics, diffuse disease was found in 88 cases (25.3%), bifurcation lesions in 62 cases (17.8%), chronic total occlusion lesions in 55 cases (15.8%), in-stent restenosis in 15 cases. The immediate angiographic outcome, six months follow-up results with major cardiac event (MACE) and angiographic follow-up at 6 months had been assessed. Results A successful stenting procedure was achieved in 99.3% patients with CHD. Acute and sub-acute stent thrombosis occurred in 2 patients, late stent thrombosis with AMI occurred in 1 patient. There was 1 case death during the 6 months follow-up. The MACE rate during hospitalization was 0.6% and during 6 months follow-up was 2.9%. Angiographic follow-up at 6 months showed that in-stent restenosis rate (ISR) was 7.1% (restenosis within the stents was 1.8%), the late loss in lesion was 0.16 mm (in-stent was 0.20 mm). The target vessel revascularization (TLR) rate was 5.4%. Conclusion Cypher~ TM stent implantation in CHD is safe and effective, and the ISR rate and TLR rate are significantly lower than that of bare metal stents.