Aim To study the dynamic change of postprandial lipid after a fat meal in patients of normotriglyceridemic type 2 diabete. Methods Subjects were assigned to two groups:the observed group of 25 fasting normotriglyceridemic type 2 diabetic patients; the healthy control group of 20 normal subjects. Postprandial lipids were measured after a fatty test meal. Results Postprandial TG concentrations of the two groups are all raised. TG peak times were all approximate 4 h in the two groups. TG concentrations at 8 h were significantly higher than fasting TG levels in case group (p<0.05), but were no significantly different in control group (p<0.05). A slight postprandial decrease in HDL-C was observed in both groups with no significant difference between groups nevertheless, and there were no difference between diabetics and controls. Postprandial changes in total cholesterol and LDL cholesterol were weak after the test meal. The correlative coefficients of TG-AUC, TG-IAUC and TG levels at 4 h were the biggest (p<0.05). Conclusions The postprandial dyslipidemia usually appears before fasting dyslipidemia in patients with type 2 diabetes mellitus. It is necessary to measure fasting TG level and 4 hour TG level to see if the triglyceride metabolism is abnormal.