Aim To investigate the anti-oxidation and-inflammation function of probucol in the elderly patients with low extremity atherosclerosis disease(LEASD) by measuring plasma cholesterol,oxidized low density lipoprotein(ox-LDL) and inflammation parameters before and after treatment. Methods 54 patients were divided into treatment group(n=33) and control group(n=21).Patients in the treatment group took probucol besides the routine therapy.Patients in the control group only took the routine drugs.The total treatment phase was 12 weeks.All patients did not take any lipid-lowering drugs and other anti-oxidants.Before and after the treatment,the plasma cholesterol,ox-LDL,high-sensitive C reactive protein(hs-CRP),interleukin-1β(IL-1β) and tumor necrosis factor-α(TNF-α)were measured. Results After treatment,the levels of hs-CRP, IL-1β,ox-LDL and cholesterol decreased significantly(p<0.05);the differences in inflammation factors,ox-LDL and cholesterol concentration between the two groups were statistically significant(p<0.05). Conclusions Probucol could decrease the concentration of plasma cholesterol in the old patients with LEASD.Probucol could reduce the plasma level of ox-LDL,hs-CRP and IL-1β significantly,indicating its good effect of anti-inflammation and-oxidation.