Aim To study the value of detecting plasma lipoprotein(a)(Lp(a)),fibrinogen(Fig)and high-sensitivity C-reactive protein(hs-CRP)in the anticipation and diagnosis of coronary heart disease(CHD). Methods 166 suspected cases of CHD undergone coronary arteriongraphy were classified into CHD group and nonCHD group.All the subjects were drawn 2mL peripheral blood.And the plasma samples were segregated.Lp(a),Fig and hs-CRP were evaluated and analyzed in both of these two groups. Results The concentration of Lp(a),Fig and hs-CRP was significantly higher in CHD patients than that in the nonCHD subjects(p<0.01).The sensitivity of the markers of Lp(a),hs-CRP and Fig were 0.739,0.63 and 0.565 respectively.The specificity of detecting all the three markers(0.919)was higher than that of single marker detecetion of either Lp(a)(0.703)or Fig(0.757)or hs-CRP(0.865). Conclusion Combined detection of three markers of Lp(a),Fig and hs-CRP may help improve the anticipation and diagnosis of CHD.