Aim Effects of captopril on angiotensin Ⅱ type 1 receptors (AT1R) and angiotensin Ⅱ type 2 receptors (AT2R) were studied in excess load-pressured hypertrophied cardiac muscles of adult rats. Methods The experiment adopts the method of narrowing and contraction the aorta in adult and health rats,hence establishing the model of animals with hypertensions and cardiac hypertrophies. By comprehensive applications of cardiac-tube, immunity tissue chemistry, and the techniques of image disjunction, to observing changes of AT1R and AT2R on hypertrophied cardiac muscles of AC rats in rats are discussed. Results (1) Load-pressured of left-ventricular and hypertrophy aggravates increase remarkably as the pressure loading time lasts. When it comes to 6 weeks after AC, Vwt reaches (1310±55), in group SO6W it is (209±8.8, p<0.01). When captopril is used till 6 week after AC, the hypertrophy in cardiac tissue decrease to the control group. (2)AngⅡ in cardiac tissue of adult rats grows to as high as (1219.5± 30.13 g/ml), which is nearly twice as high as that of control group (613.0±132.3). After using cap, left-ventricular hypertrophied decreases more significantly than control group. (3)expression of AT1Receptors increase remarkably as the pressure loading time lasts. Expression of AT1 in LV in rats (IOD value) reaches (124±32)