Aim To study the protective effects of luomaishutong granule on myocardium after reperfusion in patients with acute myocardium infarction(AMI).Methods The research was performed on the patients with AMI whose initial ECG showed ST segment elevation and the patients who received percutaneous coronary intervention(PCI)immediately after onset.All patients were classified randomly into two groups:control group in which the patients were given routine drug treatment(50 cases)and treatment group in which the patients were given luomaishutong granule(50 cases).The course of treatment is two weeks.We examined the blood interleukin 6(IL-6)mRNA and high-sensitivity C-reactive protein(hs-CRP)levels on the 1st day,7st day after percutaneous coronary intervention.We observed the left ventricular ejection fraction(LVEF)in two dimensional echocardiography at the end of the fist week and the second week.At the same time we also observed the incidence rate of arrhythmogenesis and degree of ST segment resolution.Results The day after the PCI IL-6 mRNA and hs-CRP in the patients of the two groups increased and there is no difference between the two groups.But seven days later,IL-6 mRNA and hs-CRP were decreased much more than before(p<0.01).Compared with control group,in treatment group IL-6 mRNA and hs-CRP were also decreased(p<0.05),and the incidence rate of arrhythmogenesis and degree of ST segment resolution between the two groups had obvious difference(p<0.05),and LVEF was improved obviously(p<0.05).Conclusions Luomaishutong granule can prevent myocardial ischemia-reperfusion injury,improve myocardial reperfusion,restrain inflammatory reaction and improve LVEF.