Aim To investigate the impact of scavenger receptor class A type Ⅰ/Ⅱ(SR A iv/一七)on the clearance and distribution of oxidized low density lipoprotein(LDL)of mouse under the condition of normal diet and high lipid diet.Methods Each one of SR A iv/一七gene knock out(SR-/-)mice and wild control(SR +/+)mice was randomly picked from each strip to be identified by Southern blot and immunohistochemistry.And then,50 SR-/-and 50 SR +/+ 2-month-old male,weighting about 25 g mice were divided into 4 groups:38 SR-/-mice and 38 SR +/+ mice were fed with high lipid diet(normal food with 15% fatty and 1.25% cholesterol)for 8 weeks.The serum levels of creatinine(Cr),triglyceride(TG),total cholesterol(TC),LDL,high density lipoprotein(HDL),apolipoprotein A(apo A),apolipoprotein B(apo B)and body weight(BW)were measured at 8 weeks.12 SR-/-mice and 12 SR +/+ mice were intravenous injected 125 I labeled ox-LDL(125I-ox-LDL)through their tail veins after 3 days high lipid diet.10 min and 3 h after injection,blood samples were harvested from 6 mice by cutting the tail,1 h and 6 h after injection,blood samples were harvested again respectively from eye veins.After humanly killed,the heart,liver,spleen,lung,kidney,stomach,intestines,fat as well as muscle samples were harvested and carefully weighted after circulation was perfused with 5 mL PBS at 4℃.The radiation activity was determined in a multiple-channel gamma counter.Results No significant difference of serum levels of lipid were found between SR-/-and SR +/+ mice fed with