Aim To explore the clinic,neuroimage and cerebrovascular hemodynamics changes in patients with chronic progressive occlusion of middle cerebral artery stem.Methods Seventy five patients with middle cerebral artery stem occlusion were measured by MRI,CT and transcranial Doppler.Results Sixty five patients(86.7%)presented cerebral ischemic symptom and sign.Seventy patients(93.3%) showed different cerebral infarction in MRI or CT.The hypoperfusion watershed infarct and lacunar infarct were most common.The blood flow velocity of occlusion side middle cerebral artery sample depth remarkably reduced in 60 patients(80.0%).Seventy patients(93.3%)showed blood flow velocity compensative acceleration of the occlusion side anterior cerebral artery.Forty five patients(60.0%) showed blood flow velocity compensative acceleration of the occlusion side posterior cerebral artery.Conclusions For patients with chronic progressive occlusion of middle cerebral artery stem,transcranial Doppler and neuroimage might help to evaluate the patient' condition and prognosis,they might be important and objective index in understanding the compensative state of collateral circulation and in studying deeply the pathologic mechanism of ischemic cerebrovascular disease.