Aim To study dynamic changes of serum von Willebrand factor(vWF) and high sensitivity C-reactive protein(hs-CRP) in renovascular hypertensive rats,and to investigate the effect of vWF and hs-CRP in the deployment of atherosclerosis(As) and stroke. Methods vWF and hs-CRP were measured with enzyme linked immunoabsorbent assay(ELISA),the results were compared with the control group and sham-opetated group. Results At the end of 4,8,12 weeks after the operation,the concenrations of serum vWF and hs-CRP were significantly increased compared with the control group and sham-operated group;the blood pressure were increasing in the hypertensive group after the operation,and the concenrations of serum vWF and hs-CRP were increasing simultaneously. Conclusion When the blood pressure were increasing,the concenrations of serum vWF and hs-CRP were increasing simultaneously;vWF and hs-CRP played vital roles in As.The high concenrations of serum vWF and hs-CRP might be the risk factors to ischemic stroke.