Aim To investigate the association of apolipoproteinA5(ApoA5) gene polymorphisms of patients with coronary heart disease(CHD)and the degree of coronary artery stenosis. Methods Using polymerase chain reaction-restriction fragmentpolymorphisms of patients with CHD and the degree of length polymorphism methods,the genotypes of 260 patients with CHD confirmed by coronary angiography were analyzed,the levels of coronary artery stenosis were characterized by the numbers of diseased vessels and Gensini scores. Results Serum triglyceride level of the patients with ApoA5-1131CC genotype and c.553T allele carriers were obviously higher than that of the patients with ApoA5 c.553GG genotype and-1131T allele carriers,but the Gensini scores were not significantly different among them,and the distribution for the genotyopes of ApoA5 genetic variants were also not statistically different among variable number of coronary diseased vessels.The number of coronary diseased vessels and Gensini scores had strongly positive correlation with the presence of diabetes(r=0.141 and 0.143,p<0.05),and obviously negative correlation with the level of serum high density lipoprotein cholesterol(r=-0.129 and-0.164,p<0.05). Conclusions ApoA5 gene polymorphisms are remarkably associated with the level of triglyceride,but not the extent of coronary artery stenosis among CHD patients.