Aim To investigate clinical characteristic of women ≤45 years old with coronary heart disease.Methods Coronary risk factors,angiographic characterization and revascularization of young women ≤45 years old(group A,n=123)were retrospectively analyzed,compared with that of women >45 years old(group B,n=119).Results Among group A,64(52.0%)patients had hypertension,21(17.0%)patients had diabetes,32(26.0%)patients had hypercholesterolemia,each of which was higher than that of group B(p<0.05);43(35.0%)patients had a history of myocardial infarction,which was similar to group B.Group A were more likely to have angiographically zero and single-vessel disease(p<0.05),and less likely to have three-vessel disease(p<0.05)compared with group B.Drug therapy and single-vessel coronary percutaneous intervention were more often performed for group A than group B(p<0.05).Conclusions Women ≤45 years old had relatively less coronary risk factors and less extensive disease,and hypertension was an important risk factor.No lower morbidity of myocardial infarction was revealed.More attention should be paid on prevention and therapeutic management of young women with coronary heart disease.