Aim To observe the efect of cilostazol on the serum levels of inflammatory cytokine in acute coronary syndrome.Methods 60 selected patients were randomly divided into two groups:basic treatment group(conventional medication plus atorvastatin)and cilostazol group(basic treatment plus cilostazol).The change of some indicator levels,including blood lipids,tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),high sensitivity C-reactive protein(hs-CRP)was measured after three weeks of treatment.Clinical therapeutic effect and adverse reactions was monitored.Results After the treatment,the serum levels of cholesterol,triglyceride and low density lipoprotein cholesterol(LDLC)in both groups decreased slightly(p<0.05),but there was no significance in the decreased degree between both groups.The increase of high density lipoprotein cholesterol(HDLC)was observed in both groups,but the increased degree was significantly higher in cilostazol group than in basic treatment group(p<0.01).The serum levels of TNF-α,IL-1β,hs-CRP declined in both groups(p<0.05),but the degree of reduction of them was greater in cilostazol group than in basic treatment group(p<0.01).The reduction of TNF-α and IL-1β was negatively correlated with the increase of HDLC in cilostazol group(r=-0.38,P=0.04;r=-0.39,P=0.03).Medication group could obviously ease chest pain with no adverse reactions.Conclusion The use of cilostazol joint atorvastatin on the basis of conventional treatment,compared with atorvastatin alone,could furtherly increased HDLC,reduced inflammatory cytokine concentration,promoted the stability of atherosclerotic plaque.