Aim To investigate the effects of platelet derived growth factor(PDGF) on the expression of vascular cell adhesion molecular-1(VCAM-1) and the adhesion of monocyte-VSMC.Methods GEArray Gene Array and RT-PCR technique were used to analyse the mRNA expression of VCAM-1 in VSMC after incubated with PDGF for 0 min、20 min、6 h.Meanwhile,the adhesion of monocyte-VSMC was detected by adhesion assay.Results The mRNA expression of VCAM-1 was significantly induced by PDGF,as compared with control group.PDGF-induced VCAM-1 accumulation was appeared at 20 min,and significantly increased at 6 h.PDGF also enhanced the adhesion rate of monocyte and VSMC.Conclusions The results demonstrated that PDGF significantly induced the expression of VCAM-1 in VSMC and enhanced monocyte bind to VSMC.This suggested that PEGF played an important role in early injured lesion and contribution to monocytes in circulation adheresion and migration across the endothelium.