Aim To study the blood plasma levels and significance of uPA,u-PAR,t-PA and PAI-1 in patients with ischemic cardio-cerebral-vascular disease.Methods ELISA was used to measure the blood plasma levels of uPA,uPAR,t-PA and PAI-1 in patients with acute cerebral infarction,acute myocardial infarction and unstable angina pectoris.Results Compared with the control group,(1)uPA level increased slightly at acute stage in patients with cerebral infarction(p> 0.05),while obviously fell back at restoration stage(p< 0.05);uPA level increased significantly at acute stage(p< 0.01)and increased more;t-PA level was obviously lower(p< 0.01),while PAI-1 significantly higher(p< 0.01) at acute stage;PAI-1 decreased to normal level while t-PA level was different from the control group at restoration stage.(2)u-PAR level increased obviously at acute stage(p< 0.05)and increased more at restoration stage(p< 0.01) in patients with acute myocardial infarction,uPA levels were nearly normal at both stages;t-PA and PAI1 levels were obviously higher at acute stage(p< 0.01) but decreased obviously at restoration stage till a normal PAI-1 level and a still higher level of t-PA (p< 0.05).(3)u-PAR level increased in patients with unstable angina pectoris at acute stage(P <0.01) while fell back at restoration stage after two weeks