Aim To study the effect of survival time of the patients who had non-ST-segment elevation acute coronary syndrome with different treatments. Methods Patients suffered successively from non-ST-segment elevation acute coronary syndrome were chosen initially in 14 third-class or second-class hospitals in 10 cities of Liaoning, with questionaire filled in and follow-up when the patients discharged from hospital after 30 days, 90 days, and 180 days, to get 900 complete data. All patients were divided into interventional therapy group and drug treatment group. Observational target included the patients' characters of base line, clinical interference measure and end point events. Results Mean age of patient was 61.1±10.7 years in the interventional therapy group and 65.9±10.8 years in the drug treatment group, history of congestive cardiac failure and smoking in the past and incidence of cerebral accident in the interventional therapy group were fewer than those in the drug treatment group (P<0.05). The incidence rate of reangina pectoris attacks, congestive cardiac failure, rate of death in follow-up 90 and 180 days, nonfatal myocardial infarct, congestive cardiac failure in the interventional therapy group was fewer than that in the drug treatment group(P<0.05). Using drug in follow-up 90 and 180 days, the rate of using drug, such as aspirin, clopidogrel, low molecular heparin, stain, calcium antagonist in the interventional therapy group was higher than that in the drug treatment group. Survival rate in interventional therapy group was higher than that of the drug treatment group, but there was no significant difference between the interventional therapy group and drug treatment group (P>0.05). Conclusion Interventional therapy can reduce incidence rate of myocardial infarct in period of hospital and follow-up 180 days.