Aim To investigate the plasma concentration of amino-terminal pro-brain natriuretic peptide (NT-proBNP) and prognosis impact in patients suffering from of cerebrovascular accident. Methods We selected 137 patients suffering from acute cerebrovascular accident in our department, from August 2005 to April 2006; and 106 healthy people, who came for body-check, as control. All the people received blood test for NT-proBNP, and all patients received echocardiogram examination for left ventricular ejection fraction (LVEF), Glasgow coma score (GCS) and Glasgow outcome score (GOS). According to the NT-proBNP result, the patients were divided into two groups:the high concentration group and the low concentration group. We compared the NT-proBNP concentration between the cases and control, the incidence of heart failure between different concentration groups of NT-proBNP;analyzed the linear correlation relationship between the concentration of NT-proBNP and GCS and GOS. Results The plasma concentrations of NT-proBNP in cerebral infarction group, cerebral hemorrhage group, and subarachnoid hemorrhage group were higher than in control (P<0.01), further more, the subarachnoid hemorrhage group showed highest level than the other groups (P<0.05). The high NT-proBNP concentration group showed the same incidence of heart failure as low group (P>0.05). There were negative linear correlation relationship between the plasma concentration of NT-proBNP and GCS (r=-0.696, P=0.039), GOS (r=-0.726, P=0.008). Conclusions cerebrovascular accident can independently cause the raise of plasma concentration of NT-proBNP, the degree of that can perhaps reflect the severity and prognosis of disease.