Aim To compare the efficacy of probucol and atorvastatin in treatment of coronary heart diseases (CHD) with hyperlipidemia. Methods 119 patients with hyperlipidemia and CHD were randomly divided into three groups,received probucol 0.5 g bid or atorvastatin 10 mg qd or two drugs together. After 12 weeks,the result of treadmill exercise ECG test,total cholesterol (TC),triglyceride (TG),high density lipoprotein cholesterol (HDLC),low density lipoprotein cholesterol (LDLC),oxidized low density lipoprotein (ox-LDL),superoxide dismutase (SOD),malondialdehyde (MDA),and other indicators were studied. Results The serum TC and LDLC levels were significantly lowered (P<0.01) in three groups; HDLC level significantly increased in atorvastatin group(P<0.01),but the ox-LDL,SOD and MDA did not change significantly. ox-LDL and MDA decreased significantly in probucol group (P<0.001),SOD increased (P<0.001),but HDLC decreased (P<0.01). ox-LDL and MDA decreased significantly (P<0.001),SOD increased (P<0.001),HDLC did not change significantly in combined group. In three groups,treadmill exercise ECG test positive rate reduced after treatment and the number of angina attack reduced within two weeks before the end of research,probucol group was more significant than atorvastatin group (P<0.05),the combined group was more significant than the other two groups (P<0.01). Conclusion Probucol is a safe and effective drug for treating hypolipidemic and reducing angina attack. Its combination with atorvastatin is safe,and the efficacy is more visible.