Aim Through the confer of concentration of placenta growth factor(PLGF) and interleukin-10 (IL-10) to explore its early prediction and prognostic value in acute coronary syndrome (ACS) patients. Methods 90 patients were divided into experimental sub-STEMI group, NSTEMI/UAP group, SAP group and control group. The concentration of PLGF and IL-10 were measured by the method of enzyme linked immunosorbent assay (ELISA). The risk of follow-up cardiovascular events were detected during 30 days and 3 months, then the results were statisticly analyzed. Result The serum level of PLGF was higher in STEMI group and NSTEMI/UAP group than that of SAP group, but the concentration of IL-10 was lower in STEMI group and NSTEMI/UAP group than that of SAP group (P<0.01). The risk of cardiovascular events were increased in patients with higher serum level of PLGF, which was decreased in patients with higher serum level of IL-10 during 30 days and 3 months of follow-up. There was an inverse correlation between the serum level of PLGF and IL-10. Conclusions PLGF may be early indicators of ACS powerful, the balance between PLGF and IL-10 is a major determinant of outcome in patients with ACS.